Release date: September 15, 2026
Expiration date: September 14, 2028
Estimated Time of Completion: 30 minutes
Description
Cleveland Clinic and Immune Deficiency Foundation collaborated to develop education to transform general clinicians from reactive symptom managers to proactive diagnostic detectives, enabling them to recognize hidden primary immunodeficiency (PI) patients within their existing practice, shift from a "treat-and-release" mindset to systematic pattern analysis, and initiate appropriate diagnostic workups and referral pathways that lead to life-changing diagnoses for patients who have been suffering with unrecognized immune dysfunction.
The on-demand webcast, The Ripple Effect: How One Diagnosis Changes Everything, examines the common autoimmune and inflammatory manifestations of primary immunodeficiencies, emphasizes immune dysregulation as a key warning sign of inborn errors of immunity, and reviews how precision medicine has transformed treatment approaches for patients.
Learning Objectives
- Discuss autoimmune and inflammatory manifestations that occur frequently in patients with primary immunodeficiencies.
- Add immune dysregulation to the Inborn Errors of Immunity (IEI) warning signs.
- Identify how precision medicine/therapy has changed our approach in treating patients with inborn errors of immunity.
Target Audience
The online series is designed for front-line clinicians, including physicians, nurses, physician assistants, and pharmacists, of any specialty caring for patients with hidden primary immunodeficiency.
Accreditation
In support of improving patient care, this activity has been planned and implemented by Cleveland Clinic Center for Continuing Education and Immune Deficiency Foundation (IDF). Cleveland Clinic Center for Continuing Education is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
Physicians / American Medical Association (AMA)
Cleveland Clinic Foundation Center for Continuing Education designates this internet enduring activity for a maximum of 0.50 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Participants claiming CME credit from this activity may submit the credit hours to the American Osteopathic Association for Category 2 credit.
Nurses / American Nurses Credentialing Center (ANCC)
Cleveland Clinic Center for Continuing Education designates this internet live activity for a maximum of 0.50 ANCC contact hours.
Physician Assistants / American Academy of PAs (AAPA)
Cleveland Clinic Center for Continuing Education has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 0.50 AAPA Category 1 CME credits. PAs should only claim credit commensurate with the extent of their participation.
Accreditation Council of Pharmacy Education (ACPE)
Cleveland Clinic Center for Continuing Education designates this knowledge-based activity for a maximum of 0.50 hours. Credit will be provided to NABP CPE Monitor within 60 days after the activity completion.
Universal Activity Number: JA0000192-9999-26-404-H01-P
Certificate of Participation
A certificate of participation will be provided to other health care professionals for requesting credits in accordance with their professional boards and/or associations.
Activity Director and Faculty
Activity Director
James Fernandez, MD, PhD
Vice Chair of Research
Department of Allergy and Immunology
Cleveland Clinic
Cleveland, OH
Planning Committee
Maria Holztrager, PA-C
Jeanette Kubicki, CNS
Jessica Reno, PharmD
Faculty
Mark Ballow, MD
Division of Allergy and Immunology
Morsani College of Medicine, USF
Johns Hopkins All Children’s Hospital
St. Petersburg, FL
CME Disclaimer
The information in this educational activity is provided for general medical education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient's medical condition. The viewpoints expressed in this CME activity are those of the authors/faculty. They do not represent an endorsement by The Cleveland Clinic Foundation. In no event will The Cleveland Clinic Foundation be liable for any decision made or action taken in reliance upon the information provided through this CME activity.
Disclosures
In accordance with the Standards for Integrity and Independence issued by the Accreditation Council for Continuing Medical Education (ACCME), The Cleveland Clinic Foundation Center for Continuing Education requires resolution of all faculty conflicts of interest to ensure CME activities are free of commercial bias. All relevant financial relationships have been mitigated.
| Mark Ballow, MD |
| CSL Behring |
Consulting (Ended: 12/31/2025)
Teaching and Speaking |
| Pharming |
Advisor or review panel participant |
All other individuals have indicated no relationship which, in the context of their involvement, could be perceived as a potential conflict of interest.
Acknowledgment
The Cleveland Clinic Center for Continuing Education acknowledges educational grants for partial support of this activity from:
ADMA Biologics, Inc.
CSL Behring
Grifols
Takeda Pharmaceuticals
This CME activity was produced by the Cleveland Clinic Foundation Center for Continuing Education and Immune Deficiency Foundation.
