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Alpha-1 Foundation Series

Cholestatic and Advanced Liver Disease, Risk Factors, Testing and Treatments in Pediatric Patients with Alpha-1 Antitrypsin Deficiency

Release date: October 25, 2022
Expiration date: October 25, 2025

Estimated Time of Completion: 30 minutes

Description

Participate in the on-demand webcast series designed for healthcare professions to improve knowledge and competence in diagnostics and treatment of Alpha-1 Antitrypsin Deficiency (AATD). The Cholestatic and Advanced Liver Disease, Risk Factors, Testing and Treatments in Pediatric Patients with Alpha-1 Antitrypsin Deficiency webcast provides a patient testimonial and addresses the following questions:

  • When should a person be tested for Alpha-1 based on liver findings?
  • What are the risk factors for liver disease in Alpha-1?
  • How should the child with AATD be followed and treated?

Learning Objectives

  1. Apply current guidelines and recommendations for Alpha-1 Antitrypsin Deficiency testing for liver-affected children.
  2. Review clinical manifestation of cholestic liver disease in newborns.
  3. Assessment and management of liver-affected children with Alpha-1 Antitrypsin Deficiency.

Target Audience

The educational online series is designed for primary care practitioners, internal medicine physicians, pediatricians, pulmonologists, and other physicians, respiratory therapists, geneticists, and allied health care professionals treating patients with Alpha-1 Antitrypsin Deficiency.

Accreditation

In support of improving patient care, Cleveland Clinic Center for Continuing Education is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

American Medical Association (AMA)
Cleveland Clinic Center for Continuing Education designates this enduring activity for a maximum of 0.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Participants claiming CME credit from this activity may submit the credit hours to the American Osteopathic Association for Category 2 credit.

Activity Director and Faculty

Activity Director

James K. Stoller, MD, MS
Professor and Chairman, Education Institute
Jean Wall Bennett Professor of Medicine
Samson Global Leadership Academy Endowed Chair
Cleveland Clinic Foundation
Cleveland, OH

Faculty

Charlie Strange, MD
Professor of Pulmonary, Critical Care, Allergy, and Sleep Medicine
Medical University of South Carolina
Charleston, SC

Jeffrey Teckman, MD
Professor of Pediatrics and Biochemistry
Director, Pediatric Gastroenterology and Hepatology
Saint Louis University School of Medicine
Saint Louis, MO

Alpha-1 Parent

Erin Carr
Davison, NC

CME Disclaimer

The information in this educational activity is provided for general medical education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient's medical condition. The viewpoints expressed in this CME activity are those of the authors/faculty. They do not represent an endorsement by The Cleveland Clinic Foundation. In no event will The Cleveland Clinic Foundation be liable for any decision made or action taken in reliance upon the information provided through this CME activity.

Disclosures

In accordance with the Standards for Integrity and Independence issued by the Accreditation Council for Continuing Medical Education (ACCME), Cleveland Clinic Center for Continuing Education mitigates all relevant conflicts of interest to ensure CME activities are free of commercial bias.

The following faculty member has indicated that he may have a relationship, which in the context of his presentation(s), could be perceived as a potential conflict of interest:


James Stoller, MD, MS
CSL Behring Consulting
Teaching and Speaking
Takeda Consulting
Other activities from which remuneration is received or expected: participation on a data monitoring committee for a trial regarding alpha-1 antitrypsin deficiency
Vertex Pharmaceuticals Consulting
Other activities from which remuneration is received or expected: consulting regarding alpha-1 antitrypsin deficiency
Grifols Consulting
Teaching and Speaking
Arrowhead Consulting
Insmed, Inc. Consulting
Other activities from which remuneration is received or expected: regarding alpha-1 antitrypsin deficiency
23andMe Consulting
Other activities from which remuneration is received or expected: participating in research on detection of alpha-1 antitrypsin deficiency prepared teaching materials re alpha-1 antitrypsin deficiency
Teaching and Speaking
InhibRx Consulting
Other activities from which remuneration is received or expected: regarding alpha-1 antitrypsin deficiency
Dicerna Pharmaceuticals Consulting
korro Consulting
4dmt Consulting

Charlie Strange, MD
Adverum Biotechnologies, Inc. Principal or Co-Investigator of funded research
Astra Zeneca Consulting
CSL Behring Advisor or review panel participant
Grifols Principal or Co-Investigator of funded research
Takeda Principal or Co-Investigator of funded research
Vertex Pharmaceuticals Principal or Co-Investigator of funded research

Jeff Teckman, MD
Arrowhead Research Corporation Consulting
Research: Site PI
BioMarin Consulting
Centessa Consulting
Research: study design
Dicerna Pharmaceuticals Consulting
Intellia Consulting
KorroBio Consulting
Research: preclinical studies
Takeda Pharmaceutical Ltd Consulting
Vertex Pharmaceuticals Consulting
Research: site PI


All Cleveland Clinic Center for Continuing Education and Alpha-1 Foundation planners and patients have indicated that they have no relationship which in the context of their participation could be considered a conflict of interest.

This CME activity was produced by The Cleveland Clinic Center for Continuing Education and the Alpha-1 Foundation.