Bone Marrow Failure
Syndromes

Optimizing Outcomes Worldwide through Disease Understanding

Each podcast below includes one audio file and a PDF that includes CME information and a link to the online post-test. Objectives for each activity are shown below.

Podcasts
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	Changing Face of Bone Worldwide: Epidemiology and Treatment Overview
	Estimated Time: 30 minutes Release Date: February 28, 2009 Type: Podcast	Technical Requirements: iTunes/Quicktime Expiration Date: February 28, 2011 Specialties: Hematology, Oncology
	Epigenetic Advances: Correlating Response to Modification of the Clone
	Estimated Time: 30 minutes Release Date: February 28, 2009 Type: Podcast	Technical Requirements: iTunes/Quicktime Expiration Date: February 28, 2011 Specialties: Hematology, Oncology
	Preventing AML Transformation
	Estimated Time: 30 minutes Release Date: February 28, 2009 Type: Podcast	Technical Requirements: iTunes/Quicktime Expiration Date: February 28, 2011 Specialties: Hematology, Oncology
	Rationally Targeting the Molecular Underpinnings of the Disease
	Estimated Time: 30 minutes Release Date: February 28, 2009 Type: Podcast	Technical Requirements: iTunes/Quicktime Expiration Date: February 28, 2011 Specialties: Hematology, Oncology
	Diagnostic Advances: Beyond the Karyotype
	Estimated Time: 30 minutes Release Date: February 28, 2009 Type: Podcast	Technical Requirements: iTunes/Quicktime Expiration Date: February 28, 2011 Specialties: Hematology, Oncology
	Bringing Clinical Trials to Patients
	Estimated Time: 30 minutes Release Date: February 28, 2009 Type: Podcast	Technical Requirements: iTunes/Quicktime Expiration Date: February 28, 2011 Specialties: Hematology, Oncology

Activity Objectives

Changing Face of Bone Worldwide: Epidemiology and Treatment Overview

1. Describe the risk factors for developing aplastic anemia.
2. Describe the epidemiology of myelodysplastic syndromes.

Epigenetic Advances: Correlating Response to Modification of the Clone

1. Review the possible mechanisms of action of epigenetic therapy in bone marrow failure disorders including myelodysplasia.
2. Discuss the results of recent studies which address the question of whether response to epigenetic therapy results from loss of the malignant clone or reversal of epigenetic abnormalities.

Preventing AML Transformation

1. Review of treatments having demonstrated that they could have an impact on natural history of MDS and its progression (especially to AML).

Rationally Targeting the Molecular Underpinnings of the Disease

1. Discuss the pathophysiology of PNH and its therapy.
2. Review the efficacy and safety of lenalidomide in del(5q) MDS.

Diagnostic Advances: Beyond the Karyotype

1. Explain the role of cytogenetics in the diagnosis of MDS and limitations of this technology with regard to diagnostic yield.
2. Identify techniques to detect and the diagnostic implications of novel recurrent clonal lesions in MDS.

Bringing Clinical Trials to Patients

1. Discuss some of the obstacles to performing clinical trials in a community setting.
2. Review a new model for clinical trial delivery in a community setting.
3. Demonstrate how a Patient Contact Registry can be an effective means of recruiting patients for clinical trials.
4. And explain how patient educators can instruct patients how to find clinical trials and how to contact Trial Coordinators.

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