Table 3. Dosing Adjustments for Lepirudin

Creatinine Clearance (ml/min)	Serum Creatinine (mg/dl)	Adjusted Infusion Rate
		% of Standard Initial Infusion Rate	mg/kg/hr
45 to 60	1.6 to 2.0	50%	0.075
30 to 44	2.1 to 3.0	30%	0.045
15 to 29	3.1 to 6.0	15%	0.0225
<15	>6.0	AVOID OR STOP INFUSION
Hemodialysis patients		Administer 0.1 mg/kg every other day only if the aPTT falls below the lower therapeutic limit of 1.5

 

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