Table 2. Dosage Parameters for Sildenafil, Vardenafil, and Tadalafil 8-10
| Parameter | Sildenafil | Vardenafil | Tadalafil |
|---|---|---|---|
| Initial Dose | 50 mg | 10 mg | 10 mg |
| Dosing Range | 25-100 mg | 2.5-20 mg | 5-20 mg |
| Maximum Dose | 100 mg | 20 mg | 20 mg |
| Maximum Dosing Frequency | 1 dose/day | 1 dose/day | 1 dose/day |
| Dose Adjustments | Age > 65 years, hepatic impairment: 25 mg Severe renal impairment (CrCl < 30 ml/min): 25 mg Concomitant medications: See full prescribing information |
Age > 65 years: 5 mg Moderate hepatic impairment: initial 5 mg, max 10 mg Mild, moderate, severe renal impairment: No adjustment Concomitant medications: See full prescribing information |
Age > 65 years: no dosage adjustment Mild or moderate hepatic impairment: max 10 mg once daily Severe hepatic impairment: not recommended Moderate renal impairment: initial 5 mg once daily, max 10 mg every 48 hours Severe renal impairment (CrCl < 30 ml/min) on hemodialysis: max 5 mg Concomitant medications: See full prescribing information |
| Onset | Take 60 minutes prior to sexual activity | Take 60 minutes prior to sexual activity | Take prior to anticipated sexual activity |