Table 4. Guidelines for Replacement Dosing with Factor VIII and Factor IX *

 
Desired Plasma Factor
Level (% of normal)
Initial Dose
Duration of
Therapy
 
VII
IX
VIII
IX
VIII
IX
Type of Hemorrhage

Mild hemarthrosis
Superficial hematoma
Oropharyngeal or dental
Severe epistaxis
Persistent hematuria
30%
20 - 30%
15 IU/kg
20 - 30 IU/kg
q 8-12 h
over
1-2 days
q 12-24 h
over
1-2 days
Major CNS trauma or hemorrhage;
   lumbar puncture or    epidural anesthesia
Surgery
Retroperitoneal hemorrhage
Dental extraction with
   nerve block
Severe GI bleeding
80-100%
80-100%
>50 IU/kg
50 IU/kg
q 8-12 h over at least 10-14 days*
q 12 h
over
at least
10-14
days †

Abbreviations: CNS: central nervous system, GI: gastrointestinal.† Continuous infusion recommended to avoid peak and trough level fluctuations.
Reference: Lozier JN, Kessler CM. In: Hoffman R, et al, editor. Hematology: Basic Principles and Practice 3rd ed. New York: Churchill Livingstone p. 1883-1904.

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