|
Product
(Manufacturer)
|
Source
|
Viral
Inactivation Procedure
|
Average
Cost
Per Dose ($)a,b |
| High-purity (SA: >160 U/mg protein) | |||
| MonoNine® (Aventis Behring) |
Human
plasma
|
Sodium thiocyanate |
8,260
|
| AlphaNine-SD®
(Alpha Therapeutic) |
Human
plasma
|
Solvent and detergent |
7,700
|
| BeneFix® (Genetics Institute) |
Recombinant
|
Immunoaffinity chromatography |
8,820
|
| a Cost based on average wholesale price and represents the drug cost to the pharmacy department; b Cost based on the dose required to acheive a FIX level 100% of normal for a 70-kg patient; Abbreviations: SA=specific activity; *Adapted from: Shord SS, Lindley CM. Coagulation products and their uses. Am J Health-Syst Pharm 2000;57:1403-20 and DiMichele D, Neufeld EJ. Hemophilia: A new approach to an old disease. Hematol Oncol Clin North Am 1998;12:1315-44. | |||